Why Gut Health Matters | St. Louis Functional Medicine

Your Gut Is a Barrier, Not Just a Tube

The gut lining is a single layer of cells thick.
Its job is to:

  • Absorb nutrients
  • Keep harmful particles out
  • Regulate inflammation
  • Communicate with the brain
  • Support hormone metabolism

Damage to this lining—through antibiotics, stress, poor diet, infections, or surgery—can cause “leaky gut,” which increases inflammation throughout the body.

The Gut Microbiome: Your Internal Ecosystem

You have trillions of bacteria living in your gut.
They regulate:

  • Blood sugar
  • Serotonin and dopamine
  • Thyroid conversion
  • Estrogen metabolism
  • Immune system tone
  • Histamine levels
  • LDL particle oxidation
  • Bile acid recycling
  • Vitamin absorption

When this ecosystem becomes disrupted, symptoms begin to appear—slowly at first, then rapidly.

Signs Your Gut Is Disrupted

Patients often describe:

  • Fatigue
  • Bloating
  • Brain fog
  • Weight gain
  • Constipation
  • Loose stools
  • Food sensitivities
  • Joint pain
  • Morning stiffness
  • Skin rashes
  • Anxiety
  • Poor sleep
  • Night sweats
  • Hormone irregularities

These are the patterns we evaluate during a functional medicine visit.

Gut Health and Hormones Are Closely Intertwined

The gut helps regulate:

Estrogen

Impaired gut function → estrogen dominance → heavy periods, PMS, weight gain.

Testosterone

Gut dysbiosis affects metabolic pathways needed for testosterone synthesis.

Thyroid

20% of T4 to T3 conversion happens in the gut.

Cortisol

Stress weakens the gut lining, fueling inflammation.

See: Hormone Therapy.

Gut Health and Metabolic Health Are the Same Conversation

A disrupted gut leads to:

  • Higher insulin levels
  • Higher inflammation
  • More sugar cravings
  • Lower mitochondrial output
  • Stubborn weight gain
  • Increased LDL oxidation
  • Higher risk of metabolic syndrome

See: Insulin Resistance.

The Gut–Brain Axis

Your gut communicates with your brain through neurotransmitters and the vagus nerve.

Poor gut health →
• Anxiety
• Depression
• Mood swings
• Brain fog
• Cognitive slowdown

This ties directly into our internal blog on Brain Fog.

Circulation & Gut Health

Patients are surprised to learn that gut inflammation worsens:

  • Venous insufficiency
  • Leg swelling
  • Skin discoloration in the legs
  • Restless legs
  • Slow wound healing

Learn more:

  • Varicose Veins

Gut inflammation increases pressure in the venous system, impairing lymphatic drainage and increasing swelling.